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Targeting DUBs: A Novel Strategy for Cancer Therapy DUBs can be divided into six families based on their different structures: ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs), ovarian-tumor proteases (OTUs), JAMM/MPN domain–associated metallopeptidases (JAMMs), Machado–Joseph disease protein domain proteases (MJD), and monocyte chemotactic protein-induced protein (MCPIP) (Stone et al., 2004

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