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Its key feature lies in the competitive utilization of the same substrate by iNOS (also known as Nos2) and Arg1: the former generates NO and is closely associated with pro-inflammatory effects, whereas the latter produces ornithine and polyamines and participates in tissue repair and immune regulation ( Under classical pro-inflammatory stimulation (such as LPS/IFN-γ), iNOS expression is upregulated and catalyzes the conversion of Arg into NO and citrulline

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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Wang Z.-H., Zhan-Sheng H